Aquatic Phlorotannins and Human Health: Bioavailability, Toxicity, and Future Prospects

نویسندگان

چکیده

Medicinal chemists and pharmacognosists have relied on terrestrial sources for bioactive phytochemicals to manage treat disease conditions. However, minimal interest is given sea life, especially macroalgae their inherent phytochemical reserves. Phlorotannins are a special class of mainly predominant in brown algae marine estuarine habitats. formed through the polymerization phloroglucinol residues derivatives via polyketide (acetate–malonate) pathway. Studies over past decades implicated phlorotannins with several bioactivities, including anti-herbivory, antioxidants, anti-inflammatory, anti-microbial, anti-proliferative, anti-diabetic, radio-protective, adipogenic, anti-allergic, anti-human immunodeficiency virus (anti-HIV) properties. All these activities reflected applications as nutraceuticals cosmeceutical agents. This article reviews chemical composition phlorotannins, biological roles, applications. Moreover, very few studies phlorotannin bioavailability, safety, toxicity been thoroughly reviewed. The paper concludes by suggesting exciting research questions further studies.

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ژورنال

عنوان ژورنال: Natural Product Communications

سال: 2021

ISSN: ['1555-9475', '1934-578X']

DOI: https://doi.org/10.1177/1934578x211056144